It was found that except for CTNND2 and ITGA2, the mRNA expression changes of the rest 12 junctional genes all coincided well with their changes in TCGA and GSE31210 cohorts in that the mRNA expression levels of CDH15, CDH17, CDH24, CLDN6, CLDN12, DSG2, ITGA11, ITGB4, and PKP3 were increased and the mRNA expression levels of CLDN18, ITGA8, and ITGAL were decreased in 232 lung cancer cell lines compared with these in ciliated cells (Supplementary Figure S4). The gene discussed is CTNND2; the disease is lung cancer.