Molecular docking results suggested that triptolide was the appropriate PTGS1, PTGS2, and TNF inhibitors.<h4>Conclusion</h4>Our findings provide an essential role and basis for further immune inflammatory studies into the molecular mechanisms of TwHF and PTGS1, PTGS2, and TNF inhibitor development in RA. The gene discussed is TNF; the disease is rheumatoid arthritis.