ASOs also increased the expression of wild-type sodium voltage-gated channel alpha subunit 1 (SCN1A) gene, which is known to be mutated in Dravet syndrome, a rare genetic brain disease characterised by lifelong epilepsy (Hsiao et al., 2016). Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.