Furthermore, up-regulation of ASPP2 sensitizes hepatocytes to TNF-α-induced apoptosis.<h4>Conclusion</h4>Our novel findings show the critical role of ASPP2 in inflammatory immunoregulatory mechanism of ALI and provide a rationale to target ASPP2 as a refined therapeutic strategy to ameliorate acute liver injury. This evidence concerns the gene TP53BP2 and acute respiratory distress syndrome.