Furthermore, <i>LRP1B</i> allele frequency was negatively correlated with the top 1% CDR3 sequences (<i>r</i> = -0.55, <i>p</i> = 0.033) and positively correlated with tumor shrinkage (<i>r</i> = 0.68, <i>p</i> = 0.007). The gene discussed is LRP1B; the disease is neoplasm.