At present, there are many bone metabolic markers to evaluate the risk of OS fracture, such as boney containing protein (BGP), total type 1 collagen amino terminal extender peptide (TPINP), β-Crosslaps (β-CTX), parathyroid hormone (PTH) and insulin-like growth factors-1 (IGF-1), etc. The detection of these above indicators reflects the status of bone turnover, which helps to judge the diagnosis and classification of osteoporosis, and effectively predicts the risk of hip fracture in the elderly. Here, IGF1 is linked to hip fracture.