S1PR3 and acute respiratory distress syndrome: However, the function of S1PR3 in ARDS has not been fully elucidated.<h4>Methods</h4>We used a murine lipopolysaccharide (LPS)-induced ARDS model and an LPS- stimulated ECs model to investigate the role of S1PR3 in anti-inflammatory effects and endothelial barrier protection during ARDS.<h4>Results</h4>We found that S1PR3 expression was increased in the lung tissues of mice with LPS-induced ARDS.