CASP1 and Glucose intolerance: Although the fecal microbiome did not fully explain the glucose intolerance and increased caspase-1 signal in the brain (Fig. S4 and S5), we found significant differences in the composition of microbes of the experimental diets compared to control and each other (Figs. 4, 5), an outcome that has been previously documented in studies using other diet paradigms [103–107].