Emerging evidence indicates that oncogenic signaling, such as CTNNB1, PI3K/PTEN/AKT/mTOR, p53, NF-κB, and RAS/RAF/MAPK signaling significantly regulates the tumor microenvironment by recruiting immunosuppressive cells and decreasing anti-tumor immune cells infiltration to promote tumor progression [33–35]. Here, TP53 is linked to neoplasm.