ACE-overexpressing EPC-EXOs (ACE-EPC-EXOs) inhibit cellular senescence, EC oxidative stress, apoptosis, and dysfunction, thereby improving brain neurovascular injury in elderly mice with ischemic stroke, through the activation of the miR-17-5p/PTEN/PI3K/Akt signaling pathway [103]. The gene discussed is PTEN; the disease is ischemic stroke.