Stenotrophomonas, an opportunistic pathogen with increased colonization/infection in cancer patients [57], exhibited extensive positive associations with the hypermethylation of genes, including multiple TSGs in CRC, such as ESR1, RASSF5, DIRAS1, CADM1, ST5, GJB2, FAM172A, and HIVEP3. The gene discussed is ESR1; the disease is infection.