Stenotrophomonas, an opportunistic pathogen with increased colonization/infection in cancer patients [57], exhibited extensive positive associations with the hypermethylation of genes, including multiple TSGs in CRC, such as ESR1, RASSF5, DIRAS1, CADM1, ST5, GJB2, FAM172A, and HIVEP3. This evidence concerns the gene ESR1 and colorectal carcinoma.