Models of the initial approach demonstrated an association between overall cognitive impairment at year 2 and baseline levels of IL-8 (OR = 0.85, 95%CI: 0.72–0.98, p = 0.02), as well as CRP (OR = 2.8, 95%IC: 1.10–7.66, p = 0.03). This evidence concerns the gene CXCL8 and Cognitive impairment.