However, intermittent systemic sgp130-Fc dosing reversed CCI-induced increases in IL-6 sensitive chemokines MIG, IP-10, and MIP-1β, which are known to perpetuate neuroinflammation in other neurological diseases like encephalitis, MS, and Alzheimer’s disease [17], where IL-6 signaling also plays a role. Here, IL6 is linked to early-onset autosomal dominant Alzheimer disease.