In this issue, Guleray Lafci et al. demonstrate that a non-synonymous missense inactivating genetic variant in TRPV5 (transient receptor potential cation channel subfamily V member 5) causes a novel form of autosomal recessive hypercalciuria [3], concluding a decades long search for TRPV5 variants in heritable hypercalciuria. This evidence concerns the gene TRPV5 and Hypercalciuria.