POT1 and angiosarcoma: Nonetheless, by analysing the index case it is possible to suppose that this family harbours a broader spectrum of POT1-TPD, since the patient was diagnosed with two STS (other than angiosarcomas) and a PTC, already described as associated with POT1 mutation, but not related to this specific PV, neither considered in the surveillance recommendations as a POT1-TPD [1, 17, 19].