By utilizing the ROC curve (AUC > 0.6) to assess the prognostic value of hub genes in the PPI network26, 5 out of 14 hub genes, namely, TNF, SOCS3, JUN, TNFAIP3, and CXCL9 showed potential indications as potential infection biomarkers (Table 6). This evidence concerns the gene TNFAIP3 and infection.