Oncolytic viruses (OVs) replicate and selectively kill cancer cells, leading to the release of tumor antigens in an immunologically favorable milieu enriched of Damage and Pathogens Associated Molecular Patterns (DAMPs and PAMPs) that activate Pattern Recognition Receptors (PRR) [33] leading to effective antigen presentation, T cell infiltration and activation [11]. Here, NECTIN1 is linked to neoplasm.