A recent autopsy study suggested that compared to other neurodegenerative diseases, the prevalence of co-pathology is increased in AD with approximately 41–55% of individuals with AD having α-synuclein pathology, typically associated with Lewy body dementia and Parkinson’s Disease, and 33–40% of individuals having TAR DNA-binding protein 43 (TDP-43) pathology, associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) and Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)27. Here, TARDBP is linked to Alzheimer disease.