MAPT and Alzheimer disease: We note that our result of higher anterior NFT burden in the ERC of low Braak cases appears inconsistent with the recent postmortem study by Llamas-Rodríguez et al. that characterized NFT burden in 10 preclinical AD cases (age range 59–84 years), and found higher tau in the posterior-lateral subfields: ECL, ELc and ECs (lateral portion of ERC), and increased anterior tau in older individuals (age range 75–84 years)44.