CASP3 and neoplasm: Immunohistochemical analysis of the tumor tissues further showed a significant reduction in the OSMR and Ki67 levels and increase in Cleaved caspase 3 in B21 mAb alone, Cisplatin alone and in combination with B21 in A2780 bearing mice as compared to OSM-stimulated or control IgG treated (Fig. 5e, f).