We further examined the expression of integrins ITGAV, ITGB3 and ITGA3 in the tumor samples by immunohistochemistry and found that integrin expression was significantly reduced in mice treated with B21 in combination with cisplatin at a higher level compared to monotherapy in A2780-CisR resistant cell line injected tumors (Supplementary Fig. 6b, c). The gene discussed is ITGB3; the disease is neoplasm.