OSMR and cancer: Since we observed that OSMR expression directly associates with cancer stemness and EMT markers (Fig. 2e), we investigated the effect of OSMR inhibition on cancer stemness in cisplatin-resistant ovarian cancer cell lines using colony formation and spheroid formation assays and found that the treatment of B21 anti-OSMR antibody reduced the colony forming abilities induced by OSM in both OVCAR8-CisR and A2780-CisR cell lines (Fig. 3e).