PTEN and neoplasm: In the PIK3CA/PTEN mutant model (PDX361836, Fig. 7b), gedatolisib, alpelisib, and everolimus induced significant tumor cell growth inhibition (TCGI) relative to vehicle (85%, 55%, 60% with p = 0.001, p = 0.043, p = 0.014, respectively), while capivasertib induced modest, non-significant TCGI (20%, p = 0.35).