Similarly, we previously showed that urinary levels of TIMP-2 as well as IGFBP7 were lower in patients with chronic kidney disease due to ADPKD as compared with healthy controls, even though beforehand it was hypothesized that urinary TIMP-2 levels should increase in patients with ADPKD in response to multiple repetitive acute ischemic events due to cyst growth and compression of surrounding tissue23. Here, TIMP2 is linked to chronic kidney disease.