Moreover, FBXO7 overexpression led to cell cycle arrest (Supplementary Fig. 6b) and apoptosis induction (as evidenced by increased cleavage of caspase 3, Supplementary Fig. 6c) in HCC cells grown in serine/glycine-free (−SG) medium, which were prominently restored by K37R mutant of PRMT1, but not wild-type PRMT1. This evidence concerns the gene CASP3 and hepatocellular carcinoma.