Interestingly, p53 signature was positively correlated with the mRNA level of FBXO7 (Supplementary Fig. 7d), implying that therapeutic strategies targeting FBXO7–PRMT1–PHGDH axis might be applicable for HCC patients with low p53 signature, which requires further investigation. The gene discussed is FBXO7; the disease is hepatocellular carcinoma.