IHC analysis of 45 paired human HCC samples showed that FBXO7 protein level was downregulated in HCC tissues relative to normal adjacent tissues (Fig. 7a, b), while PRMT1 protein level and PHGDH R236 mono-methylation level were both upregulated (Fig. 7c–f). This evidence concerns the gene PRMT1 and hepatocellular carcinoma.