In our study, we found that FBXO7 is downregulated in HCC and acts as a tumor suppressor in HCC by ubiquitinating and degrading PRMT1, which is consistent with a previous report showing that FBXO7 induces ubiquitination and degradation of hepatoma up-regulated protein (HURP)30. Here, FBXO7 is linked to hepatocellular carcinoma.