VDR and cytomegalovirus infection: Similar to what has been observed previously in cytomegalovirus infections [64], our findings might indicate not only downregulation of VDR gene expression during ZIKV replication but also a reduction in the responsiveness of monocytes to VD3 treatment as a result of inhibition of the negative feedback loop caused by the relative deficiency of VDR-associated VitD3 [49].