CYP24A1 and Zika virus infectious disease: However, the inhibitory effect of ZIKV infection on CYP24A1 expression was less pronounced in the presence of VitD3 at both 12 hpi (p = 0.0005 and 0.0058, respectively) and 48 hpi (p = 0.001 and 0.0023, respectively) (Fig. 2B).