However, it is unclear why accelerated gating in ADO II-linked mutants is associated with dominant osteopetrosis, which is also observed with a loss of ClC-7 function, whereas osteopetrosis is not observed with the HOD-associated mutations K285T and Y715C mutants. This evidence concerns the gene CLCN7 and hypopigmentation, organomegaly, and delayed myelination and development.