These findings suggest that causality may underlie the hereby established association between DNMT3A-CHIP mutations and periodontitis and perhaps also the previously proposed association of CHIP and inflammatory arthritides.79–82 CHIP is driven mostly by DNMT3A mutations and represents a significant public health risk with progressively increased prevalence in adults over 60,7,83 when the severity and prevalence of chronic inflammatory diseases increase significantly.84,85. This evidence concerns the gene DNMT3A and periodontitis.