These findings suggest that causality may underlie the hereby established association between DNMT3A-CHIP mutations and periodontitis and perhaps also the previously proposed association of CHIP and inflammatory arthritides.79–82 CHIP is driven mostly by DNMT3A mutations and represents a significant public health risk with progressively increased prevalence in adults over 60,7,83 when the severity and prevalence of chronic inflammatory diseases increase significantly.84,85. The gene discussed is STUB1; the disease is periodontitis.