Among them, resistin is a potential biomarker in periodontitis,52,53 MK and VCAM are putative risk factors for periodontitis,54,55 and RANKL drives inflammatory bone loss.56 Remarkably increased information flow in synovial mutant cells included angiopoietin-like proteins (ANGPTL), lymphotoxin-a (LT), adiponectin, collagen, and IL-6 (Figure S3E). This evidence concerns the gene TNFSF11 and periodontitis.