EGFR and neoplasm: Subsequently, RVG-displaying exosomes derived from dendritic cells successfully delivered cargo to mouse neurons and brain.31 In another study, the PS-binding domains of lactadherin (C1C2) were fused to anti-epidermal growth factor receptor (EGFR) nanobodies to form an EGa1-C1C2 recombinant protein.32 These EGa1-C1C2 proteins, upon binding to the PS on the exosomal surface, showed enhanced specific binding and uptake by EGFR-overexpressing tumor cells in a dose-dependent manner.