PYCARD and COVID-19: To visualize the effects of inflammatory kidney disease on ECs in vivo, we analyzed a digital spatial profiling dataset of collapsed glomeruli in patients with COVID-19 or HIV compared to histologically normal glomeruli from patients presenting with hematuria.56 Collapsing glomeruli showed significantly increased expression of IFN-γ, PYCARD, GBP1, and IL18 and reduced CD31 and CD34 expression (Figures 7E and S6C).