We and others have previously identified IFN signaling as a major consequence of SARS-CoV-2 infection.24,42 We therefore re-analyzed a urinary proteomics dataset collected from prospectively enrolled critically ill patients with symptoms suggestive of SARS-CoV-2 infection.42 GO analysis identified 186 non-redundant terms with a false discovery rate <0.05 (Table S2) in patients with COVID-19 compared to symptom-matched control patients that were found to be negative for COVID-19. This evidence concerns the gene IFNA1 and COVID-19.