CXCR4 and neoplasm: This interaction allows BACH1 to suppress a series of anti-oxidative genes, such as solute carrier family 7 member 11 (SLC7A11) and heme oxygenase 1 (HMOX1), while simultaneously activating genes involved in tumor metastasis, including matrix metallopeptidase 1 (MMP1), C-X-C motif chemokine receptor 4 (CXCR4), IL-11, and hexokinase 2 (HK2) (18, 22–25).