Our identification that Nup358 regulates HDAC3 and that this nucleoporin is an important player in hematopoietic progenitor homeostasis and differentiation suggests that alterations in Nup358 function might contribute to the pathogenesis of hematological cancers by impairing the differentiation of early MyPs. The gene discussed is HDAC3; the disease is hematopoietic and lymphoid cell neoplasm.