For example, chromosomal translocations involving NUP358 gene with FGFR1 lead to myelodysplastic syndrome/myeloproliferative neoplasms (MDS/MPNs) (9), while NUP358 fusions with ALK are associated with acute myeloid leukemia (10, 11). The gene discussed is RANBP2; the disease is myelodysplastic syndrome.