Prior studies have demonstrated the effect of THBS1 in modulating inflammation and kidney injury in the context of AKI.[24, 25, 26, 27] Notably, it has been previously demonstrated that THBS1 null mice are protected from renal I/R injury.[23] Additionally, other studies have also pointed to the role THBS1 plays in mediating fibrosis in CKD. Here, THBS1 is linked to chronic kidney disease.