THBS1 is well‐known for its role as an activator of latent TGF‐β1 (LTGF‐beta1), a potent mediator of fibrotic kidney disease.[38] Histological comparisons between Tgfb1−/− and Thbs1−/− mice were found to be similar across several organ systems, with both lines sharing features such as diffuse inflammation and an indistinct kidney cortico‐medullary junction. This evidence concerns the gene TGFB1 and kidney disorder.