the platelet‐derived high‐mobility group box 1 This factor has been implicated in multiple inflammatory diseases, and its exogenous introduction in ischemia/reperfusion‐induced AKI models intensifies renal damage.[17] Moreover, platelet‐derived CXCL4 is central in driving profibrotic macrophage activation and subsequent renal fibrosis.[18]. This evidence concerns the gene PF4 and acute kidney injury.