Histological analyses performed by assessing H&E-stained sections of the lung tissues indicated a reduced parenchyma area as compared to Nlrp3+/+ mice infected for 3 (Fig 6B) and 5 days post-infection (Fig 6C), corroborating our findings that patients with more inflammasome activation have increased parenchyma area, worse lung function, and severe pneumonia. The gene discussed is NLRP3; the disease is infection.