Regardless of the role of NLRP3 inflammasome in the induction of fibrotic process, the revealed balance of viral-induced intravascular coagulation versus inflammasome-mediated pulmonary inflammation contributes to our understanding of disease pathophysiology and may contribute to decisions between immune-mediated or antiviral-mediated therapies for the treatment of critical cases of COVID-19. This evidence concerns the gene NLRP3 and COVID-19.