Finally, while the cotransfer of LCMV-specific memory Smarta cells together with MOG-specific 2D2 cells into immunized Rag1−/− mice did not impact disease severity when compared to naive Smarta cells (Fig. 5J and SI Appendix, Fig. S6 F–H), memory Smarta cells did accelerate EAE disease onset (Fig. 5K), confirming that CD4+ TIA cells can contribute to the development of autoimmunity. The gene discussed is RAG1; the disease is Autoimmunity.