This response is believed to be mediated by both branches; however, early-stage hypoglycemia (75–85 mg/dL) results in PSNS activation of pancreatic α-cell islets [19] and subsequent glucagon secretion [20], although α-cell islets recruitment increases once FBG is below 100 mg/dL [19]. The gene discussed is GCG; the disease is Hypoglycemia.