The simultaneous upregulation of peroxidases CAT and GPX3 and the downregulation of antioxidant enzymes GSH, accompanied by elevated levels of MDA, HNE, HODE, and oxoODE, jointly indicate a close relationship between the peroxidation of FFA and hepatic steatosis (Fig. 3A, route 3). This evidence concerns the gene CAT and Hepatic steatosis.