Examining methionine cycle-related genes, including methionine adenosyltransferase (MAT), phosphatidyl-ethanolamine N-methyltransferase (PEMT), adenosylhomocysteinase (AHCY), and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), revealed their significantly lower expression levels in individuals with hepatic steatosis. Here, MAT1A is linked to fatty liver disease.