Our results showed the expression of ACSL5,4,3 genes significantly decreased with the severity of hepatic steatosis, and the rate-limiting enzyme CPT1A was almost not expressed in steatotic livers (Padj < 0.05, β = 45.17, post hoc Wilcoxon rank-sum test, 67 times higher in eCtrl than eHS-II). The gene discussed is ACSL5; the disease is Hepatic steatosis.