HMGCR and glioma: Statins, developed to lower cholesterol levels in the periphery target HMGCR, the rate-limiting enzyme in this pathway and affect glioma biology in multiple ways, from interfering with the dependence of GBM on cholesterol to inhibition of farnesylation of Ras or geranylgeranylation of GTPases with effects on cell proliferation and survival, cell cycle progression, migration, and invasion (35).