We examined the chromatin marks at the TERT locus and found that neuroblastoma cells with MYCN amplification and short telomeres are enriched for chromatin marks indicative of open chromatin including H3K4me3, H3K27Ac, H3K14Ac, RNA PolII, and BRD4 at the TERT promoter (Fig. 3A and B). This evidence concerns the gene BRD4 and neuroblastoma.