Following 21 days of treatment with 20 μmol/L of tazemetostat, we observed an induction in GREB1 and SPTBN2 (Supplementary Fig. S6A and S6B), genes previously shown to be transcriptionally repressed by H3K27me3 in neuroblastoma cells (39). This evidence concerns the gene SPTBN2 and neuroblastoma.