Notably, our findings show that inhibiting EZH2 (the enzymatically active subunit of PRC2) induces TERT expression and facilitates MYCN binding to the TERT promoter in neuroblastoma cells with long telomeres, suggesting that H3K27 trimethylation is the underlying mechanism responsible for silencing TERT in these cells. The gene discussed is EZH2; the disease is neuroblastoma.