The enrichment of H3K27me3 at the TERT proximal promoter in neuroblastoma cells with long telomeres, and the induction of TERT expression following EZH2 inhibition in those cell lines, support the notion that PRC2 plays an important role in repressing telomerase in telomerase-independent neuroblastoma. The gene discussed is EZH2; the disease is neuroblastoma.