Each tumor genome was classified according to their HRD and RB1 status, resulting in six groups: BRCA1-HRD & RB1 altered (n = 13); BRCA1-HRD & RB1 wild-type (n = 36); BRCA2-HRD & RB1 altered (n = 8); BRCA2-HRD & RB1 wild-type (n = 20); HRP & RB1 altered (n = 4); or HRP & RB1 wild-type (n = 45; Fig. 3A). The gene discussed is BRCA1; the disease is neoplasm.