Mutations in these genes are connected with brain diseases, including memory impairment, infantile muscular hypotonia, and cognitive impairment.[45] Those shared CNS‐related DEGs and similar defective phenotypes from the ankrd11Δ/Δ and 65kΔ/Δ animals suggest that the physiological functions of ANKRD11 and 65K in nervous systems are due to the 65K‐ANKRD11 interaction, a common molecular basis for the regulation of gene expression. Here, USP39 is linked to brain disorder.