Our results suggest that TRPM8 may contribute to tumor proliferation by controlling the PI3K-AKT-mTOR signaling pathway in PAAD.<h4>Conclusion</h4>After careful evaluation of the accumulated data, we concluded that TRPM8 has potential as a prognostic indicator and prospective therapeutic target in PAAD. This evidence concerns the gene AKT1 and pancreatic adenocarcinoma.