Notably, our study specifically clarified the Cd‐induced obstacle in the fusion between autophagosomes and lysosomes and impaired lysosomal function, as indicated by decreased activity of CTSB in vitro and in vivo, which is in keeping with previous findings on the anti‐amyloidogenic functions of CTSB.[58] Of note, these findings imply that the advanced stage of autophagic progression is prone to damage during the Cd‐induced worsening of AD pathology. This evidence concerns the gene CTSB and Alzheimer disease.