To determine the clinical relevance of SIRT5, we downloaded the raw single‐nucleus RNA sequencing (snRNA‐seq) data from postmortem frozen human brain tissues of patients with AD or healthy controls (HCs) in the GSE188545 dataset (Table S5, Supporting Information).[46] After cell filtering, a total of 75 052 single‐cell transcriptomes were obtained, and medians of 1901 and 2316 genes were detected in the AD and HC groups, respectively (Figure S12, Supporting Information). The gene discussed is SIRT5; the disease is Alzheimer disease.