PPARA has been implicated in the modulation of autophagy‐lysosomal function.[64] It was demonstrated that Cd impaired the autophagic flux by inhibiting PPARA expression, contributing to nonalcoholic fatty liver disease as well as hepatotoxicity.[65] Considering these findings, we posit that Cd exposure may inhibit the levels of SIRT5 by disturbing PPARA in Neuro‐2a cells. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.