reported that SIRT5 deficiency elevates the susceptibility to seizures induced by kainate and exacerbates neurodegeneration in the hippocampus of mice.[61] Consistent with previous studies, we analyzed the snRNA‐seq data of AD and control brains and found that the SIRT5 levels were markedly decreased in the neurons of AD brains. This evidence concerns the gene SIRT5 and Alzheimer disease.