Quantitative succinylome analysis revealed that reduced SIRT5 expression resulted in elevated succinylation of RAB7A at lysine 31 (K31), which reduced the activity of RAB7A and hindered its recruitment to RILP, leading to the blockade of autophagic flux and ultimately contributed to the progression of AD pathology and cognitive decline induced by Cd exposure. This evidence concerns the gene SIRT5 and Alzheimer disease.