SIRT5 and metabolic disease: SIRT5 modulates various crucial biological processes that have been implicated in multiple diseases, such as cancer and neurological, cardiovascular, and metabolic disorders.[59] In particular, given the diminished levels of SIRT5 in various neurodegenerative disorders, SIRT5 has been deemed a potential neuroprotective factor.[60] Liu et al. reported that SIRT5 protects against motor impairment and dopaminergic degeneration in a mouse model of PD induced by MPTP.[23b] Li et al.