FLI1 belongs to the ETS transcription factor family, whose member are strong activators or repressors of transcription with a highly conserved ETS domain.[47] Considering their high conservation, proteasomal degradation is likely to be the main mechanism of turnover for most ETS family members, including FLI1.[31, 32] Besides, FLI1's transcriptional regulation of CFD was also reported in endothelial cells by previous study, that it contributed to the onset of pulmonary arterial hypertension in systemic sclerosis.[29]. The gene discussed is FLI1; the disease is systemic sclerosis.