Another study on patients with alcohol‐associated hepatitis also proposed CFD was positively associated with disease severity, and might be a risk factor for mortality for patients.[43] In addition, CFD was also responsible to hepatic CD9‐deficient induced obesity, which was in accordance with previous clinical human studies that implicated increased serum CFD levels in obesity[44, 45, 46] and a positive correlation with body mass index.[45] Moreover, our study suggests that CD9 regulated CFD is due to FLI1 proteasomal degradation. Here, CFD is linked to obesity due to melanocortin 4 receptor deficiency.