Molecular evidence of cardiomyopathy, including inflammation marker (Tnd and Il6), fibrosis marker (Col1a1 and Col3a1), and hypertrophy marker (Nppa, Nppb, and Myh7), significantly increases when Rab7 was knocked out (Figure S8E–G, Supporting Information). This evidence concerns the gene NPPB and cardiomyopathy.