Indeed, recent work by the Brodsky lab indicates that CASP8 can cleave and activate CASP1, and that activated CASP8 can cleave the inflammatory substrates GSDMD, IL-1β, and IL-18 during Yersinia pestis infection in mouse bone marrow-derived macrophages (BMDMs) (73, –, 75). This evidence concerns the gene CASP8 and plague.