HSP90AB1 alterations are found in approximately 1% of all cancers, with the highest prevalence in glioblastoma, followed by colorectal adenocarcinoma and lung adenocarcinoma.7HSP90AB1 stabilizes VEGF-A-induced pro-angiogenic protein BAZF (BCL-6 associated zinc finger protein) and may positively regulate angiogenesis.13 The role of HSP90AB1 in glioblastoma remains unclear. The gene discussed is VEGFA; the disease is cancer.