VEGFA and cancer: VEGF-A—the prototype member of the VEGF family—predominantly regulates the process of angiogenesis in the CNS and directly interacts with VEGF receptors expressed on cancer cells, stimulating disease progression.14VEGF overexpression is an adverse prognostic factor in many cancers, including glioblastoma.15 Lastly, mutations in GRIN2A, which encodes the NMDA receptor subunit NR2A, have been associated with poor survival in melanoma,16 but its role in glioblastoma remains unclear.