In addition, the highest connectivity among the targets was RAC-alpha serine/threonine-protein kinase (AKT1), degree = 19), Mitogen-activated protein kinase 1 (MAPK1, degree = 19), and the highest connectivity in KEGG pathways were Pathways in cancer (hsa05200, degree = 50), lipid and atherosclerosis (hsa05417, degree = 27), and chemical carcinogenesis- receptor (hsa05207, degree = 27). This evidence concerns the gene MAP2K1 and atherosclerosis.