While an elevation of B2M in infants with hypoxic ischemic encephalopathy has been demonstrated in one study (Carreras et al. 2022), another provided evidence that B2M induces M2-like macrophage polarization and alters the tumor immune microenvironment toward an anti-inflammatory state (Li et al. 2022). The gene discussed is B2M; the disease is perinatal asphyxia.