Conversely, BAALC, CD34, CTGF, CYTL1, IQCJ-SCHIP1, ITGA6, MRC1, MYO5C, NT5E, SEMA6A, SPATS2L and TSPAN7 are identified as an up-regulated DEG in Ph + ALL but does not show significant differential expression in ALL. The gene discussed is NT5E; the disease is acute lymphoblastic leukemia.