Consequently, in ALL, 25 hub proteins were ascertained, encompassing ARRB2, BIRC2, BRCA1, CDC20, CHD3, CHD4, EGFR, ERG, HIST1H4A, HSPA4, HSPA5, HSPB1, ITCH, JUN, LYN, MYC, PLK1, PPP1CA, RAD51, RPL37A, SKP1, SOCS2, TP53, UBE3A and YWHAE. The gene discussed is TP53; the disease is acute lymphoblastic leukemia.