In the case of Ph + ALL, 26 hub proteins were identified, including AURKB, BCL2, CCND2, CD44, CDC25B, EFTUD2, ERG, FHL1, FYN, GRB10, HCK, HIST1H4A, HSP90AA1, HSPB1, IRF4, JUNB, MYC, RGS2, SOCS2, TIMM13, TRA2B, TRAF3IP2, TRAF6, TUBB6, VDR and ZMYND11 (Table S1 and S2). The gene discussed is TRA2B; the disease is acute lymphoblastic leukemia.