Consequently, in ALL, 25 hub proteins were ascertained, encompassing ARRB2, BIRC2, BRCA1, CDC20, CHD3, CHD4, EGFR, ERG, HIST1H4A, HSPA4, HSPA5, HSPB1, ITCH, JUN, LYN, MYC, PLK1, PPP1CA, RAD51, RPL37A, SKP1, SOCS2, TP53, UBE3A and YWHAE. Here, CHD4 is linked to acute lymphoblastic leukemia.