They may berelated to several different factors, which are seemingly linked, but far fromrestricted to, weight loss itself, as well as decreased visceral fat-associatedinflammation, incretin activity on insulin sensitivity and pancreatic endocrinefunction, incretin natriuretic effect, improvement of hypertension, among others.25 Both OAGB and RYGB are reportedly capable of producing massive weight lossalongside significant metabolic improvement, which are likely to positively affectrenal function, as observed in the current study. The gene discussed is INS; the disease is hypertensive disorder.