GCG and Bloom syndrome: In fact, BS evidently plays a nephroprotective role throughmultiple mechanisms, such as the decrease in visceral fat volume and consequentreduction of chronic low-grade inflammation, the improvement of glycemic metabolismmediated by the activation of incretins, and antihypertensive effects associatedwith natriuretic properties of GLP-1 alongside weight loss itself.33 However, in individuals with kidney disease classified as stage 3 or worsealready installed, the reversal rates after bariatric procedures are notsignificant, despite all other metabolic benefits.34