FGF19 and biliary liver cirrhosis: In patients with intrahepatic or extrahepatic cholestatic (liver) diseases (eg, periampullary tumors, primary biliary cholangitis, alcoholic hepatitis, and biliary atresia), bile salt synthesis is suppressed, likely as a cytoprotective mechanism by the inhibitory actions of FGF19.15, 16, 17, 18, 36