Under physiological conditions, FGF19 is produced in an FXR-stimulated fashion in the terminal ileum; however, cholestatic conditions (eg, primary biliary cholangitis and alcoholic hepatitis) trigger hepatic FGF19 production, which likely suppresses bile salt synthesis through auto- or paracrine signaling.15, 37. The gene discussed is FGF19; the disease is primary biliary cholangitis.