After filtering for SNVs with MAF less than 1%, individuals with 10% or higher SNV genotypes missing, SNVs out of Hardy–Weinberg equilibrium (P value <1 × 10−50) and individuals of non-EUR, 2850 females of EUR with breast cancer and 739,537 SNVs were included in the discovery GWAS for variants associated with TP53 and PIK3CA mutation status. This evidence concerns the gene PIK3CA and breast cancer.