To identify germline variants associated with TP53 or PIK3CA somatic mutations in tumors, we identified existing datasets with GWAS-level germline variant information, somatic mutation information for TP53 and PIK3CA, and demographic and clinical information such as age of diagnosis, tumor subtype defined by hormonal (ER and PR) status and HER2 amplification. Here, ESR1 is linked to neoplasm.