TP53 and breast cancer: After filtering for SNVs with MAF less than 1%, individuals with 10% or higher SNV genotypes missing, SNVs out of Hardy–Weinberg equilibrium (P value <1 × 10−50) and individuals of non-EUR, 2850 females of EUR with breast cancer and 739,537 SNVs were included in the discovery GWAS for variants associated with TP53 and PIK3CA mutation status.